Endocrine Abstracts

Introduction: D-aspartic acid (D-AA) is involved in the regulation of spermatogenesis by influencing hormonal biosynthesis and secretion, resulting in an increased sperm concentration and progressive motility. Coenzyme Q10 (CoQ10) correlates positively with sperm concentration and motility at high concentrations, and it plays an antioxidant role, improving sperm motility and fertilization rate in ICSI cycles. Finally, low concentrations of zinc (Zn) have been found in azoosper...

Introduction: Treatment of adrenal insufficiency (AI) in the last years has been object of important changes due to the development of a dual-release preparation of hydrocortisone (Plenadren®). Hydrocortisone dual-release therapy contemplates a once-daily tablet that allows more closely mimicking the physiological circadian rhythm cortisol, thus avoiding overexposure.Objective: The aim of the study was to value effects of Plenadren administration on...

Background: In patients with Klinefelter syndrome (KS) morbidity and mortality seem to be higher than general population, this depending on a wide number of possible comorbidities. Impaired metabolic profile, increased risk of venous thrombosis and the consequent increase of cardiovascular diseases might play a key role in this condition as well as reduced bone mineral density and higher fracture risk. Nowadays testosterone replacement therapy (TRT) is the first-choice treatme...